Oral Reverse-Micellar Drug Delivery & Targeting Technology
OraRem™ is a broad-based proprietary bio-enabling drug delivery and drug targeting platform technology that enables oral delivery of traditionally poorly absorbable therapeutic molecules.
The essential feature of the OraRem™ technology is that it enhances the absorption of therapeutic molecules without altering their chemical form or biological integrity, as well as improving its target-tissue distribution. This improves the ability of the body to not only enhance but also control the rate and timing of absorption leading to significant and improved bioavailability and drug distribution.
Through the OraRem™ system, delivery agents or "carriers" facilitate or enable transport of therapeutic molecules across biological membranes such as those of the gastrointestinal tract, and further enable tissue-specific distribution and targeting allowing the therapeutic molecules to exert their desired pharmacological effect. The delivery agents have no known pharmacological activity themselves at the intended clinical dose levels.
OraRem™ technology uses the body's natural passive transcellular transport process to enable small to medium sized and highly charged molecules to cross cell membranes through a novel “in-situ” formation of reverse-micelles. Once the drug molecule crosses the membrane, OraRem™ delivery agent(s) dissociates from the drug molecule, which then reestablishes its natural conformation and returns to its therapeutically active state.
Our OraRem™ bio-enabling technology works within the human body, responding to the multivariate external environment of the Gastro-Intestinal Tract (GIT), releasing active drug and delivery agents and concurrently forming a reverse-micellar unit which facilitates transportation and distribution of the drug.